alpha-aMine-oMega-propionic acid octaethylene glycol

Name	α-Amine-ω-propionic acid octaethylene glycol
Synonyms	H2N-PEG8-COOH Amino-PEG8-COOH Amino-PEG8-Acid amino-dPEG 8-acid H2N-PEG8-CH2CH2COOH α-AMine-ω-propionic acid octaethylene glycol α-Amine-ω-propionic acid octaethylene glycol alpha-aMine-oMega-propionic acid octaethylene glycol 27-Amino-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid
CAS	756526-04-2

Molecular Formula	C19H39NO10
Molar Mass	441.51
Density	1.128±0.06 g/cm3(Predicted)
Boling Point	547.1±50.0 °C(Predicted)
Appearance	solid or viscous liquid
pKa	4.28±0.10(Predicted)
Storage Condition	-20°C
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

biological activity	NH2-PEG9-acid is a non-cleavable ADC linker containing 9 units of PEG, which can be used to synthesize antibody-coupled drugs (ADC). NH2-PEG9-acid is also a PROTAC linker, belonging to the PEG class. It can be used to synthesize PROTAC molecules.
target	Non-cleavable PEGs
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-10 22:29:15